"I've spoken with someone very close to the case, she is out of her mother's home," journalist Lara Spencer said on Good Morning America.
Britney was reportedly "doing well" while an investigation into Britney's treatment
continued, a source told ABC News.
The authorities decided to act after Mrs Campbell, a part-time beautician, appeared with Britney on GMA. In the interview she said she gave her daughter botox because other children taking part in beauty pageants had also had it.
"Everyone is doing it and talking about it. We are not doing anything illegal," she said.
Britney said that she sometimes cried during the injections but that she believed she looked better afterwards because botox got rid of her "wrinkles". She also said that she waxed her legs.
Photographs on GMA showed Britney with a bag of ice on her face in apparent discomfort.
After the programme aired, Trent Rhorer, executive director of the San Francisco Human Services Agency, told KGO-TV that officials wanted to talk to Mrs Campbell and her daughter.
"It's pretty unusual for a mum to be injecting an eight-year-old with Botox and certainly is grounds for an investigation," Mr Rhorer said.
The San Francisco Human Services Agency, which investigates reports of child abuse, received numerous calls from people concerned about Britney's well-being after the television appearance, Mr Rhorer said.
Botox, which was introduced in 1989, is known for its ability to smooth wrinkles, but it is also approved to treat other conditions including neck spasms, excessive underarm sweating and migraine headaches.
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